With hundreds of slots and plenty of table games to keep the crew busy, Mark Twain Casino in La Grange is a winning vacation spot. Complete with a beautifully landscaped and spacious RV Park, it’s a favorite of locals and visitors alike. We are located alongside the Mississippi River just north of Hannibal, MO on Hwy. 61. No matter what you’re looking for, at Mark Twain, it’s an odds-on favorite you’re going to have a great time!